NOT A WORD. Booster worked for people who received Pfizer injections in the study

People who have received Pfizer-BioNTech vaccines may derive as much benefit from a Johnson & Johnson booster as a Pfizer vaccine. ...


People who have received Pfizer-BioNTech vaccines may derive as much benefit from a Johnson & Johnson booster as a Pfizer vaccine. It is the observation of a small to study released on Sunday.

Researchers from Beth Israel Deaconess Medical Center in Boston studied 65 people who had received two injections of the Pfizer vaccine. Six months after the second dose, the researchers gave 24 of the volunteers a third dose of the Pfizer vaccine and 41 of the Johnson & Johnson vaccine. (The study was funded in part by Johnson & Johnson and has yet to be published in a scientific journal.)

Both vaccine brands have increased the number of Covid-fighting T cells, which are important for long-lasting protection and to prevent infections from turning into serious illness. But the increase in T cells delivered by the Johnson & Johnson vaccine was twice that of Pfizer.

The researchers also measured the antibodies, which provide much of the protection immediately after vaccination. Volunteers who received a third dose of Pfizer saw their antibody levels rise after two weeks, then drop by a quarter during the fourth week. The Johnson & Johnson booster, on the other hand, more than doubled antibody levels between the second and fourth week. At this point, Pfizer’s antibodies were still around 50% higher than Johnson & Johnson’s. For antibodies, this is a relatively small difference. And both levels were well above the threshold scientists believe are necessary for strong protection.

The results are somewhat different from previous studies. In October, a “mix and match”Clinical trial organized by the National Institutes of Health reported that all three licensed vaccines – from Pfizer, Moderna and Johnson & Johnson – caused an increase in antibody levels when used as a booster. But Johnson & Johnson’s shot provided a much smaller boost than the others. (The NIH has yet to release how each boost affected volunteers’ T cells.)

The difference between the two studies could be explained by the length of the delay between the injections. In the NIH trial, many volunteers received their booster shots after three or four months, while the new study waited six months.

The Johnson & Johnson vaccine appears to have benefited more from the longer wait. Unlike Pfizer and Moderna, which are made from mRNA, Johnson & Johnson’s is made from a modified cold virus. It may be important to give the immune system more time to come to a resting state before receiving this type of vaccine.

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Newsrust - US Top News: NOT A WORD. Booster worked for people who received Pfizer injections in the study
NOT A WORD. Booster worked for people who received Pfizer injections in the study
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