Can Vaccinees Develop Long Covid After Revolutionary Infection?

While some groundbreaking cases among those who are fully vaccinated against Covid-19 are inevitable, they are unlikely to result in hos...


While some groundbreaking cases among those who are fully vaccinated against Covid-19 are inevitable, they are unlikely to result in hospitalization or death. But an important question about the breakthrough infection that remains unanswered is: Can the vaccinated develop what is called the long Covid?

Long Covid refers to a set of symptoms – such as severe fatigue, brain fog, headaches, muscle pain, and problems sleeping – that can persist for weeks or months after the end of the treatment. active infection. The syndrome is not well understood, but studies suggest that between 10 and 30 percent of adults who catch the virus can suffer from a long Covid, including those who have only experienced mild illness or no symptoms.

But the vast majority of data collected over the long Covid has been collected from the unvaccinated population. The risk of developing a long Covid for fully vaccinated people who become infected after vaccination has not been studied.

While preliminary research suggests that it is, in fact, possible that a breakthrough case could result in symptoms that can persist for weeks or even months, there are still more questions than answers. What percentage of rupture cases result in persistent symptoms? How many of these people are recovering? Are the symptoms that persist after a breakthrough infection as severe as those that occur in the unvaccinated?

“I don’t think there is enough data,” said Dr Zijian Chen, medical director of the Post-Covid care center at the Mount Sinai Health System in New York. ” It is too early to tell. The population of people who get sick after vaccination is not that high at the moment, and there is no good follow-up mechanism for these patients. “

A recent study of Israeli healthcare workers published in the New England Journal of Medicine offers insight into the risk of Covid long after a breakthrough infection. Of the 1,497 fully vaccinated healthcare workers, 39 of them – about 2.6% – developed breakthrough infections. (All workers were thought to be infected after contact with an unvaccinated person, and the study was conducted before the Delta variant became dominant.)

While most breakthrough cases were mild or asymptomatic, seven of 36 workers followed at six weeks (19%) still had persistent symptoms. These long symptoms of Covid included a mixture of prolonged loss of smell, persistent cough, fatigue, weakness, labored breathing, or muscle pain.

But the study’s authors caution against drawing too many conclusions from the research. The sample size – only seven patients – is small. And the research was designed to study antibody levels in infected people, said Dr Gili Regev-Yochay, director of the Infectious Disease Epidemiology Unit at Sheba Medical Center. It was not designed to study the risk of Covid long after a breakthrough infection.

“That was not the scope of this article,” said Dr Regev-Yochay. “I don’t think we have an answer for that.

Even so, the fact that one in five healthcare workers who have had breakthrough infections still have persistent symptoms after six weeks appears to be the first indication from a peer-reviewed study that a long Covid is possible after a breakthrough infection.

“People said to me, ‘You are fully vaccinated. Why are you so careful? ‘ Said Dr. Robert M. Wachter, professor and director of the Department of Medicine at the University of California, San Francisco. “I’m still on the side of I don’t want to have Covid. I don’t want to get a breakthrough infection.

Dr Wachter said that despite the many limitations of the Israeli study, the data offers more evidence that those vaccinated should continue to take reasonable precautions to avoid the virus.

“I’m going to take it at face value that one in five people, six weeks after a breakthrough case, continued to feel lousy,” Dr Wachter said. “It’s enough to make me want to wear two masks when I go to the grocery store, which isn’t that heavy anyway.”

The fact that the U.S. Centers for Disease Control and Prevention only monitors post-vaccine infections that lead to hospitalization or death makes it difficult to study peak infections. Although the CDC continues to study breakthrough infections in several large cohorts, the lack of data on all breakthrough cases remains a source of frustration among scientists and patient advocacy groups.

“It’s very frustrating not to have data at this point in the pandemic to know what happens to revolutionary cases,” said Akiko Iwasaki, immunologist at the Yale School of Medicine who conducts studies on the long Covid . “If a mild breakthrough infection turns into a long Covid, we have no idea what number is. “

Diana Berrent, founder of Survivor Corps, a Facebook group for those affected by Covid-19 which has around 171,000 members, conducted an informal survey and found 24 people who reported having persistent symptoms after a breakthrough infection. This is not a scientific sample and the cases have not been validated, but the poll shows the need for more data on groundbreaking cases, Ms Berrent said.

“You can’t extrapolate it to the general population, but it’s a very strong signal that the CDC must demand the reporting of every revolutionary case,” Ms. Berrent said. “We cannot know what we are not counting.”

But some experts predict that the wave of new cases caused by the spread of the Delta variant will unfortunately lead to more groundbreaking cases in the months to come. Dr Chen of Mount Sinai said it will be several months before patients with Covid long from a breakthrough infection are enrolled in studies.

“We are waiting for these patients to come to our doors,” said Dr. Chen.

Despite the lack of data, one thing is clear: getting the vaccine will reduce the risk of becoming infected and becoming Covid for a long time, said Athena Akrami, a neuroscientist at University College London who collected and published the data. nearly 4,000 long Covid patients after having developed Covid herself a long time after a fight in March 2020 with Covid-19.

“These are simple calculations,” said Dr. Akrami. “If you reduce infections, the likelihood of a long Covid will automatically drop. “

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Newsrust - US Top News: Can Vaccinees Develop Long Covid After Revolutionary Infection?
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