They Call It a ‘Women’s Disease.’ She Wants to Redefine It.

She held on to her dream of having children, but in 2001, just after her 40th birthday, the pain in her abdomen grew unbearable. On Sept....

She held on to her dream of having children, but in 2001, just after her 40th birthday, the pain in her abdomen grew unbearable. On Sept. 11, as the Twin Towers fell, she rushed to the hospital in a fog of painkillers and underwent a hysterectomy with Dr. Isaacson. (Endometriosis pain is the leading cause of hysterectomies for American women in their 30s.)

“There was no decision,” Dr. Griffith recalled. “It was hysterectomy or death.”

Even after that, her disease returned, twice. Then in 2009, just after she had pivoted to studying endometriosis, she faced a new obstacle: cancer.

Dr. Griffith likes to say that compared to endometriosis, stage 2 breast cancer was a walk in the park. “Not like a super-beautiful day — like a stormy-day walk in the park,” she added. “But it was, like, people understood.” Colleagues wrote her cards, sent her food, extended condolences. Her dean offered her a sabbatical semester.

Dr. Griffith soon learned that the way breast cancer research was categorized was far ahead of endometriosis. Doctors used molecular tests to classify patients into subtypes, which dictated which targeted treatment they should receive. With endometriosis, “there’s no metrics,” she said. “This was this huge thing for me that was so crystallizing.”

Dr. Griffith knew that her disease, like cancer, was not one disease but many, a medusa of waving tentacles. She began talking to Dr. Lauffenburger, who had been studying breast cancer for over a decade, about how to take a similar approach to classifying endometriosis patients.

Together, they identified networks of inflammatory markers that tended to be associated with more painful manifestations of the disease and fertility, and published their findings in Science Translational Medicines in 2014. The work was cited as the first step toward creating subtypes of the disease. “That was really us together, because it was his vision of systems biology but filtered through my practical connection to the clinic,” Dr. Griffith said.

For the next year, she held lab meetings from her hospital bed in between chemotherapy sessions. “We transformed our lab meetings, literally,” said Dr. Nicole Doyle, a postdoctoral fellow in Dr. Griffith’s lab at the time. “We just showed up for her chemo treatments and would sit there with her. That diagnosis had to adapt to her life, not the other way around.”

Source Link



Africa,798,Americas,4073,Art & Culture,14655,Arts,6424,Arts & Design,1607,Asia,3204,Automobile,454,Baseball,577,Basketball,475,Books,3816,Business,5259,Celebrity,2633,Cricket,648,Crime,158,Cryptocurrency,1480,Dance,643,Defense,836,Diplomatic Relations,2496,Economy,1095,Editorial,260,Education,1194,Elections,308,Energy & Environment,3055,Entertainment,22488,Environment,3559,Europe,4152,Faith & Religion,235,Family & Life,817,Fashion & Style,3180,Finance,19636,Food & Drink,3669,Football,1102,Games,97,Gossip,10289,Health & Fitness,4008,Health Care,930,Hockey,218,Home & Garden,920,Humour,994,Latin America,49,Lifestyle,16784,Media,527,Middle East,1472,Movies,1653,Music,2576,Opinion,2903,Other,11713,Other Sports,4961,Political News,11324,Political Protests,2324,Politics,17570,Real Estate,1781,Relationship,101,Retail,3116,Science,2564,Science & Tech,9817,Soccer,210,Space & Cosmos,331,Sports,11976,Technology,3363,Tennis,540,Theater,1635,Transportation,313,Travel,2518,TV,3618,US,49,US Sports,1481,Video News,3531,War & Conflict,1069,Weird News,998,World,16144,
Newsrust - US Top News: They Call It a ‘Women’s Disease.’ She Wants to Redefine It.
They Call It a ‘Women’s Disease.’ She Wants to Redefine It.
Newsrust - US Top News
Loaded All Posts Not found any posts VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share to a social network STEP 2: Click the link on your social network Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy Table of Content